Article
Angiotensinogen genotype affects renal and adrenal responses to angiotensin II in essential hypertension.
Circulation - 23 Apr 2002
Hopkins Paul N, Hunt Steven C, Jeunemaitre Xavier, Smith Barbara, Solorio Daniel, Fisher Naomi D L, Hollenberg Norman K, Williams Gordon H
Abstract excerpt
BACKGROUND: Renovascular and adrenal responses to infused angiotensin II (Ang II) are intermediate phenotypes that may indirectly reflect tissue renin-angiotensin system activity. We examine herein angiotensinogen (AGT) as a candidate gene to help elucidate potential mechanisms for previously reported AGT linkage and association studies. METHODS AND RESULTS: Renal plasma flow and plasma aldosterone were measured...
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