Article
Analysis of phenotypic consequences of renin gene polymorphism in Lyon rats.
Journal of hypertension - 1 Apr 1997
Kaiser M, Vincent M, Kenyon C J, Gomez-Sanchez C E, Cumin F, Lodwick D, Sassard J, Samani N J
Abstract excerpt
OBJECTIVE: To investigate phenotypic consequences of renin gene polymorphism between Lyon hypertensive (LH) and normotensive (LN) rats because previously we demonstrated cosegregation of the LH allele with increased blood pressure in a cross of LH with LN rats. DESIGN: Two studies were conducted. Study 1 used a cohort of male F2 rats from a LH x LN cross. Eighty-two rats homozygous for the hypertensive (HH) renin...
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