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Article

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.

The Journal of clinical investigation - 1 Mar 2007

Zhang Wenzheng, Xia Xuefeng, Reisenauer Mary Rose, Rieg Timo, Lang Florian, Kuhl Dietmar, Vallon Volker, Kone Bruce C

Abstract excerpt

Aldosterone plays a major role in the regulation of salt balance and the pathophysiology of cardiovascular and renal diseases. Many aldosterone-regulated genes--including that encoding the epithelial Na+ channel (ENaC), a key arbiter of Na+ transport in the kidney and other epithelia--have been identified, but the mechanisms by which the hormone modifies chromatin structure and thus transcription remain unknown....

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Source

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Identifiers

PMID: 17332896
DOI: 10.1172/JCI29850
PMCID: PMC1804379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.PMID 17332896Read ↗

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