Article
Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2011
Ko Soyoung, Ahn Jungmi, Song Chung S, Kim Soyoung, Knapczyk-Stwora Katarzyna, Chatterjee Bandana
Abstract excerpt
Lysine methyltransferases modulate activities of transcription factors and transcription coregulators by methylating specific lysine residue(s). We report that the androgen receptor (AR) is methylated at lysine-630 by Set9, which was originally identified as a histone H3K4 monomethyltransferase. Alanine substitution of lysine-630 prevented AR methylation in vitro and in vivo. Set9 methylated the nuclear and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.