Article
Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 2011
Ko Soyoung, Ahn Jungmi, Song Chung S, Kim Soyoung, Knapczyk-Stwora Katarzyna, Chatterjee Bandana
Abstract excerpt
Lysine methyltransferases modulate activities of transcription factors and transcription coregulators by methylating specific lysine residue(s). We report that the androgen receptor (AR) is methylated at lysine-630 by Set9, which was originally identified as a histone H3K4 monomethyltransferase....
Topics
- Blotting, Western
- Cell Line, Tumor
- Histone-Lysine N-Methyltransferase
- Humans
- Immunoprecipitation
- Lysine
- Methylation
- Mutation
- Receptors, Androgen