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Article

Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.

American journal of physiology. Renal physiology - 15 Nov 2013

Zhang Xi, Zhou Qiaoling, Chen Lihe, Berger Stefan, Wu Hongyu, Xiao Zhou, Pearce David, Zhou Xiaodong, Zhang Wenzheng

Abstract excerpt

Aldosterone is a major regulator of Na(+) absorption and acts by activating the mineralocorticoid receptor (MR) to stimulate the epithelial Na(+) channel (ENaC). MR(-/-) mice exhibited pseudohypoaldosteronism type 1 (hyponatremia, hyperkalemia, salt wasting, and high levels of aldosterone) and died around postnatal day 10. However, if and how MR regulates ENaC transcription remain incompletely understood. Our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24026182
DOI: 10.1152/ajprenal.00202.2013
PMCID: PMC3840248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.PMID 24026182Read ↗

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