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Article

An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.

American journal of physiology. Renal physiology - 15 Feb 2013

Zhang Wenzheng, Yu Zhiyuan, Wu Hongyu, Chen Lihe, Kong Qun, Kone Bruce C

Abstract excerpt

The epithelial Na(+) channel subunit-α (αENaC) of the distal nephron is essential for salt balance. We previously demonstrated that the histone methyltransferase Dot1a and its protein partner Af9 basally repress αENaC transcription in mouse inner medullary collecting duct type 3 (mIMCD3) cells and link aldosterone-elicited chromatin modifications to αENaC transcriptional activation. Af9 DNA-binding activity has...

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Identifiers

PMID: 23152297
DOI: 10.1152/ajprenal.00537.2011
PMCID: PMC3566494

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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An Af9 cis-element directly targets Dot1a to mediate transcriptional repression of the αENaC gene.PMID 23152297Read ↗

Mineralocorticoid receptor antagonizes Dot1a-Af9 complex to increase αENaC transcription.Semantic proximity Read ↗

Dot1a contains three nuclear localization signals and regulates the epithelial Na+ channel (ENaC) at multiple levels.Semantic proximity Read ↗

Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.Semantic proximity Read ↗

Aldosterone reprograms promoter methylation to regulate <i>αENaC</i> transcription in the collecting cuctSemantic proximity Read ↗

AF10 (MLLT10) prevents somatic cell reprogramming through regulation of DOT1L-mediated H3K79 methylationSemantic proximity Read ↗

DOT1L-AF10–mediated H3K79me3 promotes NF-κB p65–dependent inflammatory activation in endothelial cellsSemantic proximity Read ↗

Cistrome of the aldosterone-activated mineralocorticoid receptor in human renal cellsSemantic proximity Read ↗

CREB trans-activation of disruptor of telomeric silencing-1 mediates forskolin inhibition of CTGF transcription in mesangial cells.Semantic proximity Read ↗

Degree of Recruitment of DOT1L to MLL-AF9 Defines Level of H3K79 Di- and Tri-methylation on Target Genes and Transformation PotentialSemantic proximity Read ↗

In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron.Semantic proximity Read ↗

Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex.Semantic proximity Read ↗

Dec1 and CLOCK Regulate Na+/K+-ATPase β1 Subunit Expression and Blood Pressure.Semantic proximity Read ↗

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