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Article

A bipartite signal regulates the faithful delivery of apical domain marker podocalyxin/Gp135.

Molecular biology of the cell - 1 May 2007

Yu Chun-Ying, Chen Jen-Yau, Lin Yu-Yu, Shen Kuo-Fang, Lin Wei-Ling, Chien Chung-Liang, ter Beest Martin B A, Jou Tzuu-Shuh

Abstract excerpt

Podocalyxin/Gp135 was recently demonstrated to participate in the formation of a preapical complex to set up initial polarity in MDCK cells, a function presumably depending on the apical targeting of Gp135. We show that correct apical sorting of Gp135 depends on a bipartite signal composed of an extracellular O-glycosylation-rich region and the intracellular PDZ domain-binding motif. The function of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17332505
DOI: 10.1091/mbc.e06-07-0629
PMCID: PMC1855014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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