Article
Differential detergent resistance of the apical and basolateral NPPases: relationship with polarized targeting.
Journal of cell science - 15 Mar 2007
Delaunay Jean-Louis, Breton Michelyne, Goding James W, Trugnan Germain, Maurice Michèle
Abstract excerpt
Targeting of glycosylphosphatidylinositol-anchored proteins to the apical surface of epithelial cells involves clustering in Triton X-100-resistant membrane microdomains or rafts. The role of these microdomains in sorting transmembrane proteins is more questionable because, unlike glycosylphosphatidylinositol-anchored proteins, apical transmembrane proteins are rather soluble in Triton X-100. They are, however,...
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