Article
COG complex-mediated recycling of Golgi glycosyltransferases is essential for normal protein glycosylation.
Traffic (Copenhagen, Denmark) - 1 Feb 2006
Shestakova Anna, Zolov Sergey, Lupashin Vladimir
Abstract excerpt
Defects in conserved oligomeric Golgi (COG) complex result in multiple deficiencies in protein glycosylation. On the other hand, acute knock-down (KD) of Cog3p (COG3 KD) causes accumulation of intra-Golgi COG complex-dependent (CCD) vesicles. Here, we analyzed cellular phenotypes at different sta...
Topics
- Adaptor Proteins, Vesicular Transport
- Base Sequence
- Glycosyltransferases
- Golgi Apparatus
- HeLa Cells
- Humans
- In Vitro Techniques
- Membrane Glycoproteins
- Models, Biological
- Multiprotein Complexes
- N-Acetylglucosaminyltransferases
- Phenotype
- Protein Processing, Post-Translational
- Qc-SNARE Proteins
- RNA Interference
- RNA, Small Interfering