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Article

Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells.

The Journal of cell biology - 17 Jan 2005

Meder Doris, Shevchenko Anna, Simons Kai, Füllekrug Joachim

Abstract excerpt

Epithelial polarization involves the segregation of apical and basolateral membrane domains, which are stabilized and maintained by tight junctions and membrane traffic. We report that unlike most apical and basolateral proteins in MDCK cells, which separate only after junctions have formed, the apical marker gp135 signifies an early level of polarized membrane organization established already in single cells. We...

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Identifiers

PMID: 15642748
DOI: 10.1083/jcb.200407072
PMCID: PMC2171597

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PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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