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Article

Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons.

Neurobiology of aging - 1 Mar 2012

Kraft Andrew D, Kaltenbach Linda S, Lo Donald C, Harry G Jean

Abstract excerpt

In Huntington's disease (HD), mutated huntingtin (mhtt) causes striatal neurodegeneration which is paralleled by elevated microglia cell numbers. In vitro corticostriatal slice and primary neuronal culture models, in which neuronal expression of mhtt fragments drives HD-like neurotoxicity, were employed to examine wild type microglia during both the initiation and progression of neuronal pathology. As neuronal...

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Identifiers

PMID: 21482444
DOI: 10.1016/j.neurobiolaging.2011.02.015
PMCID: PMC3135676

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