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Article

Sex-dependent differences in rat hepatic lipid accumulation and insulin sensitivity in response to diet-induced obesity.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Apr 2012

Nadal-Casellas Antònia, Proenza Ana Maria, Lladó Isabel, Gianotti Magdalena

Abstract excerpt

Ectopic deposition of lipids in liver and other extrahepatic tissues alters their function and occurs once adipose tissue fat storage capacity is exceeded. We investigated sexual dimorphism in the effects of dietary obesity on the liver insulin signaling pathway, as well as its connection to differences in hepatic fat accumulation. Ten-week-old Wistar rats of both sexes were fed a standard diet or a high-fat diet...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22235846
DOI: 10.1139/o11-069

Genes

PDK4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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