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Article

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity.

JCI insight - 3 May 2018

Lancel Steve, Hesselink Matthijs Kc, Woldt Estelle, Rouillé Yves, Dorchies Emilie, Delhaye Stephane, Duhem Christian, Thorel Quentin, Mayeuf-Louchart Alicia, Pourcet Benoit, Montel Valérie, Schaart Gert, Beton Nicolas, Picquet Florence, Briand Olivier, Salles Jean Pierre, Duez Hélène, Schrauwen Patrick, Bastide Bruno, Bailleul Bernard, Staels Bart, Sebti Yasmine

Abstract excerpt

Metabolic stresses such as dietary energy restriction or physical activity exert beneficial metabolic effects. In the liver, endospanin-1 and endospanin-2 cooperatively modulate calorie restriction-mediated (CR-mediated) liver adaptations by controlling growth hormone sensitivity. Since we found CR to induce endospanin protein expression in skeletal muscle, we investigated their role in this tissue. In vivo and...

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Source

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Identifiers

PMID: 29720572
DOI: 10.1172/jci.insight.98081
PMCID: PMC6012521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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