Article
Comprehensive assessment of metabolic enzyme and transporter genes using the Affymetrix Targeted Genotyping System.
Pharmacogenomics - 1 Mar 2007
Dumaual Carmen, Miao Xin, Daly Thomas M, Bruckner Carsten, Njau Reuben, Fu Dong-Jing, Close-Kirkwood Sandra, Bauer Nancy, Watanabe Nancy, Hardenbol Paul, Hockett Richard D
Abstract excerpt
The combined effects of multiple polymorphisms in several drug-metabolizing enzyme and transporter genes can contribute to considerable interindividual variation in drug disposition and response. Therefore, it has been of increasing interest to generate scalable, flexible and cost-effective technologies for large-scale genotyping of the drug-metabolizing enzyme and transporter genes. However, the number of...
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