Article
Technologies for detecting genetic polymorphisms in pharmacogenomics.
Molecular diagnosis : a journal devoted to the understanding of human disease through the clinical application of molecular biology - 1 Dec 1999
Shi M M, Bleavins M R, de la iglesia F A
Abstract excerpt
BACKGROUND: Pharmacogenomics is an emerging scientific discipline examining the genetic basis for individual variations in response to therapeutics. METHODS AND RESULTS: Genetic polymorphisms are a major cause of individual differences in drug response. Metabolic phenotyping can be accomplished by administering a probe drug or substrate and measuring the metabolites and clinical outcomes. However, this approach...
Topics
- Clinical Laboratory Techniques
- Genotype
- Humans
- Pharmacogenetics
- Phenotype
- Polymorphism, Genetic