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Article

Genotyping of eight polymorphic genes encoding drug-metabolizing enzymes and transporters using a customized oligonucleotide array.

Analytical biochemistry - 1 Jan 2007

Lu Yi, Kham Shirley Kow-Yin, Foo Toon-Chai, Ariffin Hany, Hany Ariffin, Quah Thuan-Chong, Yeoh Allen Eng-Juh

Abstract excerpt

Polymorphisms in drug-metabolizing genes may lead to the production of dysfunctional proteins and consequently affect therapeutic efficacy and toxicity of drugs. Different frequencies of polymorphic alleles among the races have been postulated to account for the observed ethnic variations in drug responses. In the current study, we aimed to estimate the frequencies of 14 polymorphisms in eight genes (TPMT, NQO1,...

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Share to Enzymes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleic Acid Hybridization

Share to Oligonucleotide Array Sequence Analysis

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Share to Polymerase Chain Reaction

Share to Polymorphism, Restriction Fragment Length

Share to Spectrometry, Fluorescence

Source

Identifiers

PMID: 17113562
DOI: 10.1016/j.ab.2006.10.006

Genes

MTHFR
NQO1
ABCB1
GSTP1
TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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