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Article

Threonine 79 is a hinge residue that governs the fidelity of DNA polymerase beta by helping to position the DNA within the active site.

The Journal of biological chemistry - 20 Sept 2002

Maitra Mausumi, Gudzelak Andrew, Li Shu-Xia, Matsumoto Yoshihiro, Eckert Kristin A, Jager Joachim, Sweasy Joann B

Abstract excerpt

DNA polymerase beta (pol beta) is an ideal system for studying the role of its different amino acid residues in the fidelity of DNA synthesis. In this study, the T79S variant of pol beta was identified using an in vivo genetic screen. T79S is located in the N-terminal 8-kDa domain of pol beta and has no contact with either the DNA template or the incoming dNTP substrate. The T79S protein produced 8-fold more...

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Identifiers

PMID: 12121998
DOI: 10.1074/jbc.M204953200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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