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Article

2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities.

Organic letters - 15 Mar 2007

Meena, Sam Mui, Pierce Kathryn, Szostak Jack W, McLaughlin Larry W

Abstract excerpt

All four 2',3'-dideoxy-3'-thio-nucleosides (ddtNTPs) function as substrates for the Y410F mutant of Deep Vent (exo-) DNA polymerase. Not only are the ddtNTPs incorporated to form the N + 1 product, but further elongations are observed in which the key step is attack of the 3'-thiol on the 5'-triphosphate. Although other polymerases are likely to differ in their use of the ddtNTPs, there does not appear to be a...

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Identifiers

PMID: 17319676
DOI: 10.1021/ol070147w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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