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Design and Discovery of New Combinations of Mutant DNA Polymerases and Modified DNA Substrates.

Chembiochem : a European journal of chemical biology - 18 Apr 2017

Rosenblum Sydney L, Weiden Aurora G, Lewis Eliza L, Ogonowsky Alexie L, Chia Hannah E, Barrett Susanna E, Liu Mira D, Leconte Aaron M

Abstract excerpt

Chemical modifications can enhance the properties of DNA by imparting nuclease resistance and generating more-diverse physical structures. However, native DNA polymerases generally cannot synthesize significant lengths of DNA with modified nucleotide triphosphates. Previous efforts have identified a mutant of DNA polymerase I from Thermus aquaticus DNA (SFM19) as capable of synthesizing a range of short,...

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PMID: 28160372
DOI: 10.1002/cbic.201600701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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