Article
Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases beta and lambda.
Nucleic acids research - 1 Jan 2007
Crespan Emmanuele, Alexandrova Ludmila, Khandazhinskaya Anastasiya, Jasko Maxim, Kukhanova Marina, Villani Giuseppe, Hübscher Ulrich, Spadari Silvio, Maga Giovanni
Abstract excerpt
We have recently shown that neither the base nor the sugar moieties of a nucleotide is an essential feature for its incorporation by DNA polymerases (pols) lambda and beta. Here we present the identification of novel non-nucleoside triphosphate (NNTP) derivatives belonging to three classes: (i) non-substrate-specific inhibitors of DNA pol lambda; (ii) substrate inhibitors which could preferentially be...
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