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Article

Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype.

Cancer - 15 Mar 2007

Konoplev Sergej, Rassidakis Georgios Z, Estey Elihu, Kantarjian Hagop, Liakou Chrysoula I, Huang Xuelin, Xiao Lianchun, Andreeff Michael, Konopleva Marina, Medeiros L Jeffrey

Abstract excerpt

BACKGROUND: CXC chemokine receptor 4 (CXCR4) expression in acute myeloid leukemia (AML) is reported to correlate with FLT3 gene mutation and poorer prognosis. The prognostic significance of CXCR4 expression in patients with AML that have a normal karyotype and no evidence of FLT3 gene mutations w...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17315232
DOI: 10.1002/cncr.22510

Genes

CXCR4
FLT3
EFS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17315232-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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