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Article

Impact of CXCR4 inhibition on FLT3-ITD-positive human AML blasts.

Experimental hematology - 1 Mar 2010

Jacobi Angela, Thieme Sebastian, Lehmann Romy, Ugarte Fernando, Malech Harry L, Koch Sina, Thiede Christian, Müller Katrin, Bornhäuser Martin, Ryser Martin, Brenner Sebastian

Abstract excerpt

OBJECTIVE: Internal tandem duplication (ITD) mutations of the FLT3 receptor are associated with a high incidence of relapse in acute myeloid leukemia (AML). Expression of the CXCR4 receptor in FLT3-ITD-positive AML is correlated with poor outcome, and inhibition of CXCR4 was shown to sensitize AML blasts toward chemotherapy. The aim of this study was to evaluate the impact of FLT3-ITD on cell proliferation and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20035824
DOI: 10.1016/j.exphem.2009.12.003
PMCID: PMC4777334

Genes

FLT3
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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