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Article

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML.

Blood - 11 Jun 2009

Zeng Zhihong, Shi Yue Xi, Samudio Ismael J, Wang Rui-Yu, Ling Xiaoyang, Frolova Olga, Levis Mark, Rubin Joshua B, Negrin Robert R, Estey Elihu H, Konoplev Sergej, Andreeff Michael, Konopleva Marina

Abstract excerpt

SDF-1alpha/CXCR4 signaling plays a key role in leukemia/bone marrow microenvironment interactions. We previously reported that bone marrow-derived stromal cells inhibit chemotherapy-induced apoptosis in acute myeloid leukemia (AML). Here we demonstrate that the CXCR4 inhibitor AMD3465 antagonized stromal-derived factor 1alpha (SDF-1alpha)-induced and stroma-induced chemotaxis and inhibited SDF-1alpha-induced...

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Share to Chemokine CXCL12
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

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Source

Open in PubMed Open full text

Identifiers

PMID: 18955566
DOI: 10.1182/blood-2008-05-158311
PMCID: PMC2699240

Genes

CXCR4
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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