Article
[Clinical relevance of chemokine receptor CXCR4].
Postepy higieny i medycyny doswiadczalnej (Online) - 23 May 2012
Gębura Katarzyna, Bogunia-Kubik Katarzyna
Abstract excerpt
Stromal cell-derived factor-1 (SDF-1/CXCL12) induces intracellular signaling pathways crucial for mobilization, migration, proliferation and survival of many cell types via CXCR4, a chemokine CXC-motif receptor, member of the G protein-coupled receptor family. Despite playing a key role in such major processes as embryogenesis, cell differentiation and organ regeneration, molecular mechanisms underlying CXCR4...
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