Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CXCR4 Overexpression is a Poor Prognostic Factor in Pediatric Acute Myeloid Leukemia With Low Risk: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group.

Pediatric blood & cancer - 1 Aug 2016

Matsuo Hidemasa, Nakamura Naomi, Tomizawa Daisuke, Saito Akiko Moriya, Kiyokawa Nobutaka, Horibe Keizo, Nishinaka-Arai Yoko, Tokumasu Mayu, Itoh Hiroshi, Kamikubo Yasuhiko, Nakayama Hideki, Kinoshita Akitoshi, Taga Takashi, Tawa Akio, Taki Tomohiko, Tanaka Shiro, Adachi Souichi

Abstract excerpt

BACKGROUND: Overexpression of CXC chemokine receptor 4 (CXCR4+) is a poor prognostic factor in adult acute myeloid leukemia (AML); however, its prognostic significance in pediatric AML is unclear. PROCEDURE: This retrospective study examined the prognostic significance of CXCR4+ in pediatric AML patients enrolled in the Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. RESULTS: In the total cohort (n...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Disease-Free Survival
Share to Japan

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Prognosis

Share to Proto-Oncogene Proteins c-kit

Share to Receptors, CXCR4

Share to Splenomegaly

Share to Survival Analysis

Source

Identifiers

PMID: 27135782
DOI: 10.1002/pbc.26035

Genes

CXCR4
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

CXCR4 Overexpression is a Poor Prognostic Factor in Pediatric Acute Myeloid Leukemia With Low Risk: A Report From the Japanese Pediatric Leukemia/Lymphoma Study Group.PMID 27135782Read ↗

Allogeneic hematopoietic stem cell transplantation can improve the prognosis of high-risk pediatric t(8;21) acute myeloid leukemia in first remission based on MRD-guided treatment.Semantic proximity Read ↗

CXCR4 expression accounts for clinical phenotype and outcome in acute myeloid leukemia.Semantic proximity Read ↗

Allogeneic haematopoietic stem cell transplantation can improve the prognosis of high-risk paediatric t(8;21) acute myeloid leukaemia in first remission based on MRD-guided treatment.Semantic proximity Read ↗

CXCR4 as a therapeutic target in acute myeloid leukemia.Semantic proximity Read ↗

Dysregulated CXCR4 expression promotes lymphoma cell survival and independently predicts disease progression in germinal center B-cell-like diffuse large B-cell lymphoma.Semantic proximity Read ↗

CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemiaSemantic proximity Read ↗

KIT mutations, and not FLT3 internal tandem duplication, are strongly associated with a poor prognosis in pediatric acute myeloid leukemia with t(8;21): a study of the Japanese Childhood AML Cooperative Study GroupSemantic proximity Read ↗

CCR4 mutations associated with superior outcome of adult T-cell leukemia/lymphoma under mogamulizumab treatment.Semantic proximity Read ↗

[Clinical relevance of chemokine receptor CXCR4].Semantic proximity Read ↗

Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.