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Article

Hypermethylation of CXCR4 promoter in CD34+ cells from patients with primary myelofibrosis.

Stem cells (Dayton, Ohio) - 1 Aug 2008

Bogani Costanza, Ponziani Vanessa, Guglielmelli Paola, Desterke Cristophe, Rosti Vittorio, Bosi Alberto, Le Bousse-Kerdilès Marie-Caroline, Barosi Giovanni, Vannucchi Alessandro M

Abstract excerpt

Constitutive mobilization of CD34(+) cells in patients with primary myelofibrosis (PMF) has been attributed to proteolytic disruption of the CXCR4/SDF-1 axis and reduced CXCR4 expression. We document here that the number of circulating CD34(+)/CXCR4(+) cells in PMF patients, as well as the cellular CXCR4 expression, was directly related to CXCR4 mRNA level and that reduced CXCR4 mRNA level was not due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18511598
DOI: 10.1634/stemcells.2008-0377

Genes

CXCR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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