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The magnitude of CXCR4 signaling regulates resistance to quizartinib in FLT3/ITD+ cells via RUNX1.

Leukemia research - 1 Jan 2023

Fukuda Seiji, Matsuda Nozomi, Shoji Tsukimi, Onishi Chie, Hirade Tomohiro, Taketani Takeshi, Pelus Louis M

Abstract excerpt

CXCR4 antagonists sensitize FLT3/ITD+ AML cells to FLT3 inhibitors; however, CXCR4 signaling can induce apoptosis in AML cells, raising the question of whether CXCR4 signaling exerts divergent effects on FLT3/ITD+ cells. The present study investigated the paradoxical function of CXCR4 in resistance to FLT3 inhibitors. The FLT3 inhibitor quizartinib significantly decreased the number of FLT3/ITD+ Ba/F3 cells,...

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PMID: 36473282
DOI: 10.1016/j.leukres.2022.106983

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