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Article

Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia.

Blood - 15 Jul 2004

Rombouts Elwin J C, Pavic Biljana, Löwenberg Bob, Ploemacher Rob E

Abstract excerpt

Recently it was shown that, analogous to normal hematopoietic cells, the level of CXC chemokine receptor 4 (CXCR-4) expression on acute myeloid leukemia (AML) cells correlates with stromal cell derived factor-1 alpha (SDF-1)-induced chemotaxis. As we speculated that an anomalous organ distribution of AML cells could affect cell survival and thus result in an altered fraction surviving chemotherapy, we examined a...

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Share to Antigens, CD34
Share to Chemokine CXCL12
Share to Chemokines, CXC

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid

Share to Mice, Inbred NOD

Share to Receptors, CXCR4

Source

Identifiers

PMID: 15054042
DOI: 10.1182/blood-2004-02-0566

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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