Article
CXC chemokine receptor 4 expression, CXC chemokine receptor 4 activation, and wild-type nucleophosmin are independently associated with unfavorable prognosis in patients with acute myeloid leukemia.
Clinical lymphoma, myeloma & leukemia - 1 Dec 2013
Konoplev Sergej, Lin Pei, Yin C Cameron, Lin E, Nogueras González Graciela M, Kantarjian Hagop M, Andreeff Michael, Medeiros L Jeffrey, Konopleva Marina
Abstract excerpt
BACKGROUND: CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation and essential for migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts unfavorable prognosis in patients with acute myeloid leukemia (AML). Nucleophosmin (NPM1) mutation is the most frequent genetic abnormality in patients with AML and predicts a favorable prognosis. In vitro studies have suggested that...
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