Article
Sensory ciliogenesis in Caenorhabditis elegans: assignment of IFT components into distinct modules based on transport and phenotypic profiles.
Molecular biology of the cell - 1 May 2007
Ou Guangshuo, Koga Makato, Blacque Oliver E, Murayama Takashi, Ohshima Yasumi, Schafer Jenny C, Li Chunmei, Yoder Bradley K, Leroux Michel R, Scholey Jonathan M
Abstract excerpt
Sensory cilium biogenesis within Caenorhabditis elegans neurons depends on the kinesin-2-dependent intraflagellar transport (IFT) of ciliary precursors associated with IFT particles to the axoneme tip. Here we analyzed the molecular organization of the IFT machinery by comparing the in vivo transport and phenotypic profiles of multiple proteins involved in IFT and ciliogenesis. Based on their motility in...
Topics
- Animals
- Animals, Genetically Modified
- Biological Transport, Active
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cilia
- Genes, Helminth
- Green Fluorescent Proteins
- Microscopy, Fluorescence