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Article

Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Nov 2002

Ralph-Williams Rebecca J, Lehmann-Masten Virginia, Otero-Corchon Veronica, Low Malcolm J, Geyer Mark A

Abstract excerpt

Stimulation of the dopamine (DA) system disrupts prepulse inhibition (PPI) of the acoustic startle response. On the basis of rat studies, it appeared that DA D2 receptors (D2Rs) rather than D1 receptors (D1Rs) regulate PPI, albeit possibly in synergism with D1Rs. To characterize the DA receptor modulation of PPI in another species, we tested DA D1R and D2R mutant mice with direct and indirect DA agonists and with...

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Identifiers

PMID: 12417685
PMCID: PMC6758013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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