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Article

A constitutively active cryptochrome in Drosophila melanogaster.

Nature neuroscience - 1 Aug 2004

Dissel Stephane, Codd Veryan, Fedic Robert, Garner Karen J, Costa Rodolfo, Kyriacou Charalambos P, Rosato Ezio

Abstract excerpt

Light-activated cryptochrome (CRY) regulates circadian photoresponses in Drosophila melanogaster. Removing the carboxy (C) terminus to create CRYDelta produces, in yeast, a light-independent, constitutively active form. Here we show that flies overexpressing CRYDelta have a longer free-running period of locomotor activity, as well as altered cycling kinetics of the clock proteins timeless (TIM) and period (PER)....

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Identifiers

PMID: 15258584
DOI: 10.1038/nn1285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A constitutively active cryptochrome in Drosophila melanogaster.PMID 15258584Read ↗

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Circadian photoreception in Drosophila: functions of cryptochrome in peripheral and central clocks.Semantic proximity Read ↗

Disruption of Cryptochrome partially restores circadian rhythmicity to the arrhythmic period mutant of Drosophila.Semantic proximity Read ↗

Veela defines a molecular link between Cryptochrome and Timeless in the light-input pathway to Drosophila's circadian clock.Semantic proximity Read ↗

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PER-TIM interactions with the photoreceptor cryptochrome mediate circadian temperature responses in Drosophila.Semantic proximity Read ↗

CRYPTOCHROME is a blue-light sensor that regulates neuronal firing rate.Semantic proximity Read ↗

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