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Article

Mechanism of photosignaling by Drosophila cryptochrome: role of the redox status of the flavin chromophore.

The Journal of biological chemistry - 21 Feb 2014

Ozturk Nuri, Selby Christopher P, Zhong Dongping, Sancar Aziz

Abstract excerpt

Cryptochrome (CRY) is the primary circadian photoreceptor in Drosophila. Upon light absorption, dCRY undergoes a conformational change that enables it to bind to Timeless (dTIM), as well as to two different E3 ligases that ubiquitylate dTIM and dCRY, respectively, resulting in their proteolysis and resetting the phase of the circadian rhythm. Purified dCRY contains oxidized flavin (FADox), which is readily...

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Identifiers

PMID: 24379403
DOI: 10.1074/jbc.M113.542498
PMCID: PMC3931024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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