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Article

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice.

Carcinogenesis - 1 Oct 2009

Lin Patrick P, Pandey Manoj K, Jin Fenghua, Raymond A Kevin, Akiyama Haruhiko, Lozano Guillermina

Abstract excerpt

Mice bearing germ line mutations of p53 develop sarcomas at a significant rate. Since they are susceptible to a variety of other malignancies, they are not ideally suited to the study of sarcomas. To test the possibility that targeted mutation of tumor suppressor genes in early mesenchymal cells...

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Share to Crosses, Genetic
Share to Gene Deletion
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Retinoblastoma

Share to Homozygote

Share to Limb Buds

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Share to Sarcoma, Experimental

Source

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Identifiers

PMID: 19635748
DOI: 10.1093/carcin/bgp180
PMCID: PMC4141195

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19635748-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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