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Article

Oncogene alterations in primary, recurrent, and metastatic human bone tumors.

1 Oct 1996

Abstract excerpt

We investigated the structure and the expression of various oncogenes in three of the most common human bone tumors-osteosarcoma (36 samples from 34 patients), giant cell tumor (10 patients), and chondrosarcoma (18 patients)-in an attempt to identify the genetic alterations associated with these malignancies. Alterations of RB and p53 were detected only in osteosarcomas. Alterations of c-myc, N-myc, and c-fos...

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Identifiers

PMID: 8891902
DOI: 10.1002/(sici)1097-4644(199610)63:1%3c37::aid-jcb3%3e3.0.co;2-0

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