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Article

Dependence of induction of osteocalcin gene expression on the presence of wild-type p53 in a murine osteosarcoma cell line.

Molecular carcinogenesis - 1 Jan 1993

Chandar N, Campbell P, Novak J, Smith M

Abstract excerpt

The p53 gene undergoes rearrangement in a high percentage of osteosarcomas, resulting in loss of its expression. A p53-null murine osteosarcoma cell line F6 was transfected with either a wild-type or a mutant p53 gene. Stably transfected cell lines were obtained, and their differentiation capabil...

Topics

Alkaline Phosphatase
Animals
Cell Differentiation
Gene Expression Regulation, Neoplastic
Genes, p53
Mice
Minerals
Mutation
Osteocalcin
Osteosarcoma
Temperature
Transfection

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Cells, Cultured

Source

Identifiers

PMID: 8280378
DOI: 10.1002/mc.2940080413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8280378-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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