Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tropomodulin expression in developing hearts of normal and cardiac mutant Mexican axolotl.

Cardiovascular toxicology - 1 Jan 2006

McLean Matthew D, Zajdel Robert W, Dube Syamalima, Thurston Harold, Dube Dipak K

Abstract excerpt

In the axolotl, Ambystoma mexicanum, a simple, recessive cardiac-lethal mutation in gene "c" results in the hearts of c/c homozygous animals being deficient in sarcomeric tropomyosin (TM) and failing to form mature myofibrils. Subsequently, the mutant hearts do not beat. A three-step model of myofibril assembly recently developed in cell culture prompted a reassessment of the myofibril assembly process in mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ambystoma
Share to Antibodies, Monoclonal
Share to Erythrocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Microscopy, Confocal

Share to Myocardium

Share to Myofibrils

Source

Identifiers

PMID: 17303917
DOI: 10.1385/ct:6:2:85

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tropomodulin expression in developing hearts of normal and cardiac mutant Mexican axolotl.PMID 17303917Read ↗

Aberrant myofibril assembly in tropomodulin1 null mice leads to aborted heart development and embryonic lethality.Semantic proximity Read ↗

Immunofluorescent confocal analysis of tropomyosin in developing hearts of normal and cardiac mutant axolotls, Ambystoma mexicanum.Semantic proximity Read ↗

The cardiac mutant Mexican axolotl is a unique animal model for evaluation of cardiac myofibrillogenesis.Semantic proximity Read ↗

Molecular and immunohistochemical analyses of cardiac troponin T during cardiac development in the Mexican axolotl, Ambystoma mexicanum.Semantic proximity Read ↗

A reduction of tropomyosin limits development of sarcomeric structures in cardiac mutant hearts of the Mexican axolotl.Semantic proximity Read ↗

Immunofluorescent studies on titin and myosin in developing hearts of normal and cardiac mutant axolotls.Semantic proximity Read ↗

Characterization of a TM-4 type tropomyosin that is essential for myofibrillogenesis and contractile activity in embryonic hearts of the Mexican axolotl.Semantic proximity Read ↗

In vivo protein synthesis in developing hearts of normal and cardiac mutant axolotls (Ambystoma mexicanum).Semantic proximity Read ↗

Confocal microscopy of a newly identified protein associated with heart development in the Mexican axolotl.Semantic proximity Read ↗

The cardiac mutant gene c in axolotls: cellular, developmental, and molecular studies.Semantic proximity Read ↗

Cardiac myofibril formation is not affected by modification of both N- and C-termini of sarcomeric tropomyosin.Semantic proximity Read ↗

Differential expression of C-protein isoforms in the developing heart of normal and cardiac lethal mutant axolotls (Ambystoma mexicanum).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.