Article
Molecular and immunohistochemical analyses of cardiac troponin T during cardiac development in the Mexican axolotl, Ambystoma mexicanum.
Journal of cellular biochemistry - 1 Jan 2007
Zhang C, Pietras K M, Sferrazza G F, Jia P, Athauda G, Rueda-de-Leon E, Rveda-de-Leon E, Maier J A, Dube D K, Lemanski S L, Lemanski L F
Abstract excerpt
The Mexican axolotl, Ambystoma mexicanum, is an excellent animal model for studying heart development because it carries a naturally occurring recessive genetic mutation, designated gene c, for cardiac nonfunction. The double recessive mutants (c/c) fail to form organized myofibrils in the cardiac myoblasts resulting in hearts that fail to beat. Tropomyosin expression patterns have been studied in detail and show...
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