Article
The cardiac mutant gene c in axolotls: cellular, developmental, and molecular studies.
Cellular & molecular biology research - 1 Jan 1995
Lemanski L F, La France S M, Erginel-Unaltuna N, Luque E A, Ward S M, Fransen M E, Mangiacapra F J, Nakatsugawa M, Lemanski S L, Capone R B
Abstract excerpt
The cardiac mutant axolotl is an interesting model for studying heart development. The mutant gene results in a failure of heart cells to form organized myofibrils and as a consequence the heart fails to beat. Experiments have shown that mutant hearts can be "rescued" (i.e., turned into normally contracting organs) by the addition of RNA purified from conditioned media produced by normal embryonic anterior...
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