Article
The cardiac mutant gene c in axolotls: cellular, developmental, and molecular studies.
Cellular & molecular biology research - 1 Jan 1995
Lemanski L F, La France S M, Erginel-Unaltuna N, Luque E A, Ward S M, Fransen M E, Mangiacapra F J, Nakatsugawa M, Lemanski S L, Capone R B
Abstract excerpt
The cardiac mutant axolotl is an interesting model for studying heart development. The mutant gene results in a failure of heart cells to form organized myofibrils and as a consequence the heart fails to beat. Experiments have shown that mutant hearts can be "rescued" (i.e., turned into normally...
Topics
- Ambystoma
- Amino Acid Sequence
- Animals
- Base Sequence
- Coculture Techniques
- Culture Media, Conditioned
- Embryonic Induction
- Endoderm
- Gene Expression Regulation, Developmental
- Heart
- Microscopy, Confocal