Article
A reduction of tropomyosin limits development of sarcomeric structures in cardiac mutant hearts of the Mexican axolotl.
Cardiovascular toxicology - 1 Jan 2007
Zajdel Robert W, Thurston Harold, Prayaga Sastry, Dube Syamalima, Poiesz Bernard J, Dube Dipak K
Abstract excerpt
The cardiac lethal mutation in Mexican axolotl (Ambystoma mexicanum) results in a lack of contractions in the ventricle of mutant embryos. Previous studies have demonstrated that tropomyosin, a component of thin filaments, is greatly reduced in mutant hearts lacking myofibril organization. Confocal microscopy was used to examine the structure and comparative amount of tropomyosin at heartbeat initiation and at a...
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