Immunofluorescent studies on titin and myosin in developing hearts of normal and cardiac mutant axolotls.

Abstract excerpt

Homozygous recessive cardiac mutant gene c in the axolotl, Ambystoma mexicanum, results in a failure of the embryonic heart to initiate beating. Previous studies show that mutant axolotl hearts fail to form sarcomeric myofibrils even though hearts from their normal siblings exhibit organized myofibrils beginning at stage 34-35. In the present study, the proteins titin and myosin are studied using normal (+/+)...

Topics

• Aging
• Ambystoma
• Animals
• Connectin
• Embryonic and Fetal Development
• Fluorescent Antibody Technique
• Heart
• Heart Defects, Congenital
• Membrane Proteins
• Muscle Proteins
• Mutation