Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Integrin alpha6 cleavage: a novel modification to modulate cell migration.

Experimental cell research - 1 Apr 2007

Pawar Sangita C, Demetriou Manolis C, Nagle Raymond B, Bowden G Tim, Cress Anne E

Abstract excerpt

Integrins play a major role in cell adhesion and migration. Previous work reported that a cleaved form of integrin alpha6 (alpha6p) was detected in invasive human prostate cancer tissue, absent in normal prostate tissue and was produced by urokinase-type Plasminogen Activator (uPA) in a plasmin-independent manner. Using site-directed mutagenesis we identified amino acid residues R594 and R595, located in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Cell Movement
Share to Integrin alpha6

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to K562 Cells

Share to Mutagenesis, Site-Directed

Share to Plasminogen Activators

Share to Prostatic Neoplasms

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 17303120
DOI: 10.1016/j.yexcr.2007.01.006
PMCID: PMC1905853

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Integrin alpha6 cleavage: a novel modification to modulate cell migration.PMID 17303120Read ↗

Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines.Semantic proximity Read ↗

Identification of a Novel Structural Variant of the α6 IntegrinSemantic proximity Read ↗

alpha6 integrin cleavage: sensitizing human prostate cancer to ionizing radiation.Semantic proximity Read ↗

Integrin clipping: A novel adhesion switch?Semantic proximity Read ↗

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.Semantic proximity Read ↗

Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites.Semantic proximity Read ↗

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.Semantic proximity Read ↗

Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin.Semantic proximity Read ↗

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.Semantic proximity Read ↗

An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.Semantic proximity Read ↗

The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins.Semantic proximity Read ↗

Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.