Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines.

Biochemical and biophysical research communications - 14 Nov 2014

Kacsinta Apollo D, Rubenstein Cynthia S, Sroka Isis C, Pawar Sangita, Gard Jaime M, Nagle Raymond B, Cress Anne E

Abstract excerpt

Cancer metastasis is a multi-step process in which tumor cells gain the ability to invade beyond the primary tumor and colonize distant sites. The mechanisms regulating the metastatic process confer changes to cell adhesion receptors including the integrin family of receptors. Our group previously discovered that the α6 integrin (ITGA6/CD49f) is post translationally modified by urokinase plasminogen activator...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Breast

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Protein-Tyrosine Kinases

Share to Integrin alpha6

Share to Neoplasm Invasiveness

Share to Prostate

Share to Receptors, Urokinase Plasminogen Activator

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 25450398
DOI: 10.1016/j.bbrc.2014.10.073
PMCID: PMC4254650

Genes

ILK
ITGA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intracellular modifiers of integrin alpha 6p production in aggressive prostate and breast cancer cell lines.PMID 25450398Read ↗

Integrin alpha6 cleavage: a novel modification to modulate cell migration.Semantic proximity Read ↗

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.Semantic proximity Read ↗

Regulation and Functions of α6-Integrin (CD49f) in Cancer BiologySemantic proximity Read ↗

Integrin clipping: A novel adhesion switch?Semantic proximity Read ↗

Identification of a Novel Structural Variant of the α6 IntegrinSemantic proximity Read ↗

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.Semantic proximity Read ↗

Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites.Semantic proximity Read ↗

Beyond adhesion: emerging roles for integrins in control of the tumor microenvironmentSemantic proximity Read ↗

The interaction between uPAR and vitronectin triggers ligand-independent adhesion signalling by integrins.Semantic proximity Read ↗

Functional elucidation and methylation-mediated downregulation of ITGA5 gene in breast cancer cell line MDA-MB-468.Semantic proximity Read ↗

Domain 2 of the urokinase receptor contains an integrin-interacting epitope with intrinsic signaling activity: generation of a new integrin inhibitor.Semantic proximity Read ↗

Inhibition of migration and invasion of carcinoma cells by urokinase-derived antagonists of alphavbeta5 integrin activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.