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Article

Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding.

The Journal of cell biology - 31 Jan 2005

Wei Ying, Czekay Ralf-Peter, Robillard Liliane, Kugler Matthias C, Zhang Feng, Kim Kevin K, Xiong Jian-Ping, Humphries Martin J, Chapman Harold A

Abstract excerpt

Urokinase-type plasminogen activator receptors (uPARs), up-regulated during tumor progression, associate with beta1 integrins, localizing urokinase to sites of cell attachment. Binding of uPAR to the beta-propeller of alpha3beta1 empowers vitronectin adhesion by this integrin. How uPAR modifies other beta1 integrins remains unknown. Using recombinant proteins, we found uPAR directly binds alpha5beta1 and rather...

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Identifiers

PMID: 15684035
DOI: 10.1083/jcb.200404112
PMCID: PMC2171741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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