Article
Distinct structural requirements for binding of the integrins alphavbeta6, alphavbeta3, alphavbeta5, alpha5beta1 and alpha9beta1 to osteopontin.
Matrix biology : journal of the International Society for Matrix Biology - 1 Sept 2005
Yokosaki Yasuyuki, Tanaka Kumi, Higashikawa Fumiko, Yamashita Keisuke, Eboshida Akira
Abstract excerpt
The extracellular matrix protein, osteopontin, is a ligand for several members of the integrin family, including alpha5beta1, alphavbeta3, alphavbeta5 and alpha9beta1. Osteopontin is a substrate for a number of extracellular proteases, including thrombin and the metalloproteases MMP-3 and MMP-7, which cleave osteopontin at sites close to or within the mapped integrin binding sites. Using affinity chromatography...
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