Article
An uncleavable uPAR mutant allows dissection of signaling pathways in uPA-dependent cell migration.
Molecular biology of the cell - 1 Jan 2006
Mazzieri Roberta, D'Alessio Silvia, Kenmoe Richard Kamgang, Ossowski Liliana, Blasi Francesco
Abstract excerpt
Urokinase-type plasminogen activator (uPA) binding to uPAR induces migration, adhesion, and proliferation through multiple interactions with G proteins-coupled receptor FPRL1, integrins, or the epidermal growth factor (EGF) receptor (EGFR). At least two forms of uPAR are present on the cell surface: full-length and cleaved uPAR, each specifically interacting with one or more transmembrane proteins. The connection...
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