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Article

Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch.

The Journal of pathology - 1 Sept 2017

Tod Jo, Hanley Christopher J, Morgan Mark R, Rucka Marta, Mellows Toby, Lopez Maria-Antoinette, Kiely Philip, Moutasim Karwan A, Frampton Steven J, Sabnis Durgagauri, Fine David R, Johnson Colin, Marshall John F, Scita Giorgio, Jenei Veronika, Thomas Gareth J

Abstract excerpt

The integrin αvβ6 is up-regulated in numerous carcinomas, where expression commonly correlates with poor prognosis. αvβ6 promotes tumour invasion, partly through regulation of proteases and cell migration, and is also the principal mechanism by which epithelial cells activate TGF-β1; this latter function complicates therapeutic targeting of αvβ6, since TGF-β1 has both tumour-promoting and -suppressive effects. It...

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Identifiers

PMID: 28608476
DOI: 10.1002/path.4923
PMCID: PMC5601247

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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