Article
Different phenotypes in human prostate cancer: alpha6 or alpha3 integrin in cell-extracellular adhesion sites.
Neoplasia (New York, N.Y.) - 1 Jan 2000
Schmelz Monika, Cress Anne E, Scott Katherine M, Bürger Friederike, Cui Haiyan, Sallam Karim, McDaniel Kathy M, Dalkin Bruce L, Nagle Raymond B
Abstract excerpt
The distribution of alpha6/alpha3 integrin in adhesion complexes at the basal membrane in human normal and cancer prostate glands was analyzed in 135 biopsies from 61 patients. The levels of the polarized alpha6/alpha3 integrin expression at the basal membrane of prostate tumor glands were determined by quantitative immunohistochemistry. The alpha6/alpha3 integrin expression was compared with Gleason sum score,...
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