Article
alpha6 integrin cleavage: sensitizing human prostate cancer to ionizing radiation.
International journal of radiation biology - 1 Jan 2000
Pawar Sangita C, Dougherty Shona, Pennington Michael E, Demetriou Manolis C, Stea B Dino, Dorr Robert T, Cress Anne E
Abstract excerpt
PURPOSE: The goal was to determine if prostate tumor cells containing a mutant alpha6 integrin would be defective in tumor re-population following clinically relevant fractionated ionizing radiation (IR) treatments. MATERIAL AND METHODS: Human prostate cancer cells derived from PC3N cells were used which conditionally expressed a cleavable, wild type form of alpha6 integrin (PC3N-alpha6-WT) or a mutated...
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