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Article

The receptor for urokinase-plasminogen activator (uPAR) controls plasticity of cancer cell movement in mesenchymal and amoeboid migration style.

Oncotarget - 30 Mar 2014

Margheri Francesca, Luciani Cristina, Taddei Maria Letizia, Giannoni Elisa, Laurenzana Anna, Biagioni Alessio, Chillà Anastasia, Chiarugi Paola, Fibbi Gabriella, Del Rosso Mario

Abstract excerpt

The receptor for the urokinase plasminogen activator (uPAR) is up-regulated in malignant tumors. Historically the function of uPAR in cancer cell invasion is strictly related to its property to promote uPA-dependent proteolysis of extracellular matrix and to open a path to malignant cells. These features are typical of mesenchymal motility. Here we show that the full-length form of uPAR is required when prostate...

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Identifiers

PMID: 24681666
DOI: 10.18632/oncotarget.1754
PMCID: PMC4039230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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